Alternative Names:
AVP; IFRC; IFNAR; IFNBR; IFN-alpha-REC;
Application:
WB IP FC
Reactivity:
Human
Dilution:
WB 1:500~1:2000 IP 1:50 FC 1:50
 Western blot analysis of IFNAR1 expression in K562 cell lysate. |
Purification:
Affinity-chromatography
Specificity:
IFNAR1 Antibody detects endogenous levels of total IFNAR1
Immunogen:
A synthesized peptide derived from human IFNAR1
Description:
Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1. Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves. Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway.
Storage Condition and Buffer:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
