Alternative Names:
ARB1; ARR1; ARRB1; Arrestin 2; Arrestin beta 1; Arrestin beta-1; Beta-arrestin-1.
Application:
WB
Reactivity:
Human
Dilution:
WB 1:500
Western blot detection of β-Arrestin 1 in K562 and Hela cell lysates using β-Arrestin 1 mouse mAb(dilution 1:500).Predicted band size:51kDa.Observed band size:51kDa.
Purification:
Affinity-chromatography
Specificity:
β-Arrestin 1 Mouse mAb detects endogenous levels of total β-Arrestin 1
Immunogen:
Recombinant human β-Arrestin 1 protein.
Description:
Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation.
Storage Condition and Buffer:
Mouse IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
