Alternative Names:
ARB1; ARR1;ARR1; ARRB1; Arrestin 2; Arrestin beta 1; Beta-arrestin-1;
Application:
WB
Reactivity:
Mouse,Rat,Human
Dilution:
WB 1:500
Western blot detection of beta Arrestin 1 in PC12,Raw264.7,MCF7 and mouse brain cell lysates using beta Arrestin 1 mouse mAb (1:500 diluted).Predicted band size:50KDa.Observed band size:50KDa.
Purification:
Affinity-chromatography
Specificity:
β-Arrestin 1 Mouse mAb detects endogenous levels of total β-Arrestin 1
Immunogen:
Purified recombinant human beta Arrestin 1 protein fragments expressed in E.coli.
Description:
Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes.During homologous desensitization,beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein;the binding appears to require additional receptor determinants exposed only in the active receptor conformation.
Storage Condition and Buffer:
Mouse IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
