Alternative Names:
NOTC1, NOTCH1, TAN1, hN1, neurogenic locus notch homolog protein 1, neurogenic locus notch homolog protein 1 precursor, notch (Drosophila) homolog 1 (translocation-associated), notch homolog 1, translocation-associated (Drosophila), translocation-associat
Application:
WB,IHC
Reactivity:
Human,Mouse,Rat
Dilution:
WB 1:500-1:2000 IHC 1:50-1:200
 Western blot analysis of Notch 1 (Cleaved-Val1744) expression in NIH 3T3 cell extract treated with etoposide |
Purification:
Affinity-chromatography
Specificity:
Notch 1 (Cleaved-Val1744) Antibody detects endogenous levels of total Notch 1 (Cleaved-Val1744)
Immunogen:
A synthesized peptide derived from human Notch 1 (Cleaved-Val1744)
Description:
Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus
Storage Condition and Buffer:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
