Alternative Names:

hWNT5A; Protein Wnt5a; Wingless type MMTV integration site family member 5A; WNT 5A protein; WNT 5A protein precursor; WNT5A;

Application:

WB ICC/IF FC

Reactivity:

Human

Dilution:

WB 1:500~1:1000 ICC/IF 1:50~1:200 FC 1:20

Western blot analysis of Wnt5a expression in HeLa cell lysate.

Purification:

Affinity-chromatography

Specificity:

Wnt5a Antibody detects endogenous levels of total Wnt5a

Immunogen:

A synthesized peptide derived from human Wnt5a

Description:

Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.