Alternative Names:
CDw156; CD156c; ADAM10; KUZ; MADM;
Application:
WB IP
Reactivity:
Human Mouse Rat
Dilution:
WB 1:500~1:2000 IP 1:50
Western blot analysis of ADAM10 expression in Jurkat cell lysate. |
Purification:
Affinity-chromatography
Specificity:
ADAM10 Antibody detects endogenous levels of total ADAM10
Immunogen:
A synthesized peptide derived from human ADAM10
Description:
The ADAM10 prodomain acts as a chaperone that stabilizes mature ADAM protein folding, and prevents target-protein shedding through inhibition of ADAM10 proteinase activity. Mature ADAM10 is the major α-secretase responsible for cleavage of Notch, APP, cadherins, and prion protein. The ADAM10 protein cleaves receptor tyrosine kinases and their associated ligands and displays a wide range of regulatory functions across related signaling pathways.
Storage Condition and Buffer:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
