Alternative Names:
CD156b; ADAM17; CSVP; TACE;
Application:
WB ICC/IF IP FC
Reactivity:
Human Mouse Rat
Dilution:
WB 1:500~1:2000 ICC/IF 1:50~1:200 IP 1:50 FC 1:100
Western blot analysis of ADAM17 expression in Hela cell lysate. |
Immunofluorescent analysis of Hela cells, using ADAM17 Antibody. |
Purification:
Affinity-chromatography
Specificity:
ADAM17 Antibody detects endogenous levels of total ADAM17
Immunogen:
A synthesized peptide derived from human ADAM17
Description:
TACE is responsible for the shedding of EGFR ligands such as amphiregulin and TNF-α. Some tumors have hyperactivated EGFR due to upregulated TNF-α production and upregulated TACE, making TACE a potential target for drug development. TACE activates Notch in a ligand-independent manner and has been shown to play a role in the development of the Drosophila nervous system.
Storage Condition and Buffer:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
